All the top seeds have gone home, all the “smart money” is down the tubes and millions of brackets are in the trash.

Even in the unpredictable world of March Madness, this is a Final Four nobody could have imagined.

Kentucky, Connecticut, Butler and Virginia Commonwealth fill out a Final Four that, by most ways of looking at it, is the most unimaginable in the history of an NCAA tournament that has never lacked surprises.

In one game in Houston on Saturday, No. 4 seed Kentucky will play No. 3 Connecticut. In the other, it will be No. 11 Virginia Commonwealth against No. 8 Butler.

“Seeds are so overrated,” Kansas coach Bill Self said, stating the obvious after his top-seeded team lost 71-61 to VCU on Sunday. “It’s about matchups. And their players could play for us any day.”

Kentucky emerged from the weekend as the new Vegas favorite, at 8-5. VCU is 7-1 – the long shot again, though nowhere near the 2,500-1 pick it was back when the season started.

NCAA Mens Final Four

National Semifinals – VCU vs Butler- Apr. 2, 2011, Saturday, 6:09 PM @ Reliant Stadium, Houston, TX.
Kentucky vs UConn- Apr. 2, 2011 Saturday, 8:49 p.m. @ Reliant Stadium, Houston, TX
National Championship Game Apr. 4, 2011, Monday, TBD @ Reliant Stadium, Houston, TX.